Two Allelic Forms of Mouse β 2-microglobulin
Abstract
Two allelic forms of mouse beta 2-microglobulin (beta 2m), the small polypeptide chain of H-2 histocompatibility antigens, have been identified. The two forms can be distinguished by NaDodSO4/polyacrylamide gel electrophoresis. All inbred mouse strains express a single beta 2m isotype. Mice heterozygous for beta 2m synthesize both forms, showing codominant expression of beta 2m alleles. In mice heterozygous for both H-2 and beta 3m, individual H-2 histocompatibility antigens associate with both beta 2m forms. Preliminary structural studies indicate differences in peptide composition between the two forms.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- February 1981
- DOI:
- 10.1073/pnas.78.2.1167
- Bibcode:
- 1981PNAS...78.1167R