Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression
Abstract
A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
- Publication:
-
Nature
- Pub Date:
- April 1981
- DOI:
- 10.1038/290372a0
- Bibcode:
- 1981Natur.290..372C