Thyrotropin-Releasing Hormone Selectively Depresses Glutamate Excitation of Cerebral Cortical Neurons
Abstract
The microiontophoretic application of thyrotropin-releasing hormone causes a selective reduction in neuronal excitation evoked by L-glutamate but not by acetylcholine in rat cerebral cortex. Thyrotropin-releasing hormone has no influence on the activity of acetylcholinesterase or on choline uptake and release from cerebral synaptosomes. This evidence for a selective interaction between a centrally acting peptide and an excitatory amino acid neurotransmitter may indicate a specific locus of thyrotropin-releasing hormone action at glutamate-activated receptor sites.
- Publication:
-
Science
- Pub Date:
- September 1979
- DOI:
- 10.1126/science.224461
- Bibcode:
- 1979Sci...205.1275R