L-aspartate: evidence for a role in cone photoreceptor synaptic transmission in the carp retina.
Abstract
A number of putative neurotransmitter substances and their antagonists were applied to the carp retina while intracellular recordings from L-type cone horizontal cells were made. Of all the substances tested, L-aspartate was found to be the most potent agent in depolarizing these horizontal cells in dark-adapted, partially light-adapted, and Co2+-treated retinas. Furthermore, DL-alpha-aminoadipate, an L-aspartate antagonist, blocked the effects of both the endogenous photoreceptor transmitter and exogenously applied L-aspartate on the horizontal cells. The results suggest that L-aspartate and the natural transmitter interact with the same population of postsynaptic receptors in the horizontal cell membrane.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 1978
- DOI:
- 10.1073/pnas.75.10.5205
- Bibcode:
- 1978PNAS...75.5205W