Escherichia coli recA Gene Product Inactivates Phage λ Repressor
Abstract
Phage lambda repressor is inactivated and cleaved into two detectable fragments during incubation with purified Escherichia coli recA gene protein in vitro, in a reaction that requires ATP. This reaction reproduces the recA-dependent inactivation of repressor that occurs in vivo during induction of the SOS functions. The proteolytic activity may reside in the recA protein itself and may be a fundamental activity of it.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- October 1978
- DOI:
- 10.1073/pnas.75.10.4714
- Bibcode:
- 1978PNAS...75.4714R