Three Hypolipidemic Drugs Increase Hepatic Palmitoyl-Coenzyme A Oxidation in the Rat
Abstract
Male rats treated with clofibrate, tibric acid, or Wy-14,643 show an 11- to 18-fold increase in the capacity of their livers to oxidize palmitoyl-coenzyme A. This provides a plausible biochemical mechanism for the action of these hypolipidemic drugs in reducing lipid concentrations in the serum.
- Publication:
-
Science
- Pub Date:
- August 1977
- DOI:
- 10.1126/science.195342
- Bibcode:
- 1977Sci...197..580L