Antischizophrenic Drugs: Chronic Treatment Elevates Dopamine Receptor Binding in Brain
Abstract
Chronic treatment of rats with the neuroleptic drugs haloperidol, fluphenazine, and reserpine elicits a 20 to 25 percent increase in striatal dopamine receptor binding assayed with [3H] haloperidol. This increase in receptor sites may account for behavioral supersensitivity to dopamine receptor stimulants in such animals and for tardive dyskinesia in patients treated with these drugs.
- Publication:
-
Science
- Pub Date:
- April 1977
- DOI:
- 10.1126/science.847477
- Bibcode:
- 1977Sci...196..326B