Elastic Model of Supercoiling
Abstract
An elastic model for the supercoiling of duplex DNA is developed. The simplest assumptions regarding the elastic properties of double-helical DNA (homogeneous, isotropic, of circular cross section, and remaining straight when unstressed) will generate two orders of superhelicity when stressed. Recent experimental results [Brady, G. W., Fein, D. B. & Brumberger, H. (1976) Nature 264, 231-234] suggest that in supercoiled DNA molecules there are regions where two distinct orders of supercoiling arise, as predicted by this model.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- June 1977
- DOI:
- 10.1073/pnas.74.6.2397
- Bibcode:
- 1977PNAS...74.2397B