Some new perspectives on the biological effects of asbestos
Abstract
A brief review of recent biochemical investigations conducted on the biological effects of asbestos is presented along with a critical appraisal of the likely mechanisms involved. Involvement of intracellular organelles such as lysosomes and mitochondria, along with changes in various tissue constituents, helps us to understand the biochemical basis of asbestosis. The central role for α-ketoglutarate metabolism and related biochemical aspects are pointed out, and a few areas where further work is needed are suggested.
- Publication:
-
Environmental Research
- Pub Date:
- 1977
- DOI:
- 10.1016/0013-9351(77)90056-1
- Bibcode:
- 1977ER.....14..487R