Opioid Activity of a Peptide, β -lipotropin-(61-91), Derived from β -lipotropin
Abstract
The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- June 1976
- DOI:
- 10.1073/pnas.73.6.1821
- Bibcode:
- 1976PNAS...73.1821C