Stimulation of prostaglandin E synthesis in cultured human umbilical vein smooth muscle cells.
Abstract
Cultured human umbilical vein smooth muscle cells secreted 1.26 +/- 0.20 mug of immunoreactive prostaglandin E (iPGE) per mg of cell protein per 24 hr (mean +/- SEM). In indomethacin, an inhibitor of prostaglandin synthesis, abolished greater than 95% of this basal iPGE production (ID50 = 1.8 nM).
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- May 1976
- DOI:
- Bibcode:
- 1976PNAS...73.1617A