3' Non-coding region sequences in eukaryotic messenger RNA
Abstract
The sequence A-A-U-A-A-A is present in six different purified messenger RNA molecules (specifically the α- and β-globulin mRNAs of rabbit and human, the immunoglobulin light chain mRN A of mouse (MOPC 21) and the ovalbumin mRN A of chicken) about 20 residues away from the 3'-terminal poly(A) sequence. In addition, a large selection of the 3' non-coding regions of rabbit and human globin mRN As (both the α- and β- globin mRN As) are 85% homologous, demonstrating that this region is significantly conserved in evolution.
- Publication:
-
Nature
- Pub Date:
- September 1976
- DOI:
- 10.1038/263211a0
- Bibcode:
- 1976Natur.263..211P