Isologous IgG-induced tolerance to benzyl penicilloyl
Abstract
INDUCTION of tolerance by haptens linked to non-immunogenic carriers1-5 is used widely, not only to investigate the cellular mechanism of tolerance6 but also as a new approach to the treatment of experimental immune disease7. A potentially therapeutic application of carrier-induced tolerance is the treatment of allergic diseases. In this respect, systemic hypersensitivity reactions to penicillin constitute a major cause of death due to anaphylaxis, and penicilloyl determinant is involved in approximately half of the cases8-10. We report here the suppression of reaginic antibody to the benzyl penicilloyl (BPO) determinant in un-primed as well as primed mice.
- Publication:
-
Nature
- Pub Date:
- May 1976
- DOI:
- 10.1038/261049a0
- Bibcode:
- 1976Natur.261...49B