H-2 gene complex restricts transfer of delayed-type hypersensitivity in mice.
Abstract
Sensitized lymphocytes can transfer a state of delayed-type hypersensitivity to soluble protein antigens to naive mice only if donor and recipient share the I-A region of the H-2 gene complex. Identity at the K or D region is not essential. The restriction is unlikely to result from ineffective homing of the injected cells or from their early destruction. It is thought to reflect a requirement for an Ir-gene controlled mechanism which governs effective interaction between sensitized T lymphocytes and antigen presented on the surface of macrophages.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- December 1975
- DOI:
- 10.1073/pnas.72.12.5095
- Bibcode:
- 1975PNAS...72.5095M