Dopamine Receptor Binding in the Corpus Striatum of Mammalian Brain
Abstract
Specific binding of [3H]dopamine to membranes from the corpus striatum of rat and calf brain appears to involve the postsynaptic dopamine receptor. Specific [3H]dopamine binding is saturable, with half-maximal binding in calf membranes at 7 nM. Apomorphine is about twice as potent as dopamine in competing for binding sites, whereas (-)-norepinephrine is 5% as potent as dopamine and isoproterenol is virtually inactive. The relative potencies of phenothiazines as inhibitors of specific dopamine binding correlates with their clinical potencies and actions on the dopamine-sensitive adenylate cyclase.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- November 1975
- DOI:
- 10.1073/pnas.72.11.4655
- Bibcode:
- 1975PNAS...72.4655B