Preferential and cooperative binding of histone I to chromosomal mammalian DNA.
Abstract
There is a strong preferential binding of histone I to lymphocyte DNA as compared to Escherichia coli DNA when large DNA fragments (2 times 10-6 daltons) are used. The binding of histone I to lymphocyte DNA and to E. coli DNA is cooperative. The distribution of preferential binding sites has been investigated on fragmented DNA. Most of the 2 times 10-6 dalton fragments were found to have at least one preferential histone I binding site, whereas most of the 2 times 10-5 dalton fragments have none.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- February 1975
- DOI:
- 10.1073/pnas.72.2.733
- Bibcode:
- 1975PNAS...72..733R