The Presence of I-Region-Associated Antigens on B Cells in Molecules Distinct from Immunoglobulin and H-2K and H-2D
Abstract
The distribution of I-region-associated antigenic specificities in murine lymphoid cells was studied by immunofluorescence. The antigens were mostly represented in B cells and in macrophages. The complexes of I-anti-I-region-associated antigens were found to be distributed throughout the lymphocyte surface both at 4° and 37°. In about two-thirds of the lymphocytes the complexes redistributed into caps after incubation with a second ligand (an anti-mouse immunoglobulin). The I-region specificities were in molecules distinct from immunoglobulin or from the molecules coded by the H-2K and H-2D regions.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- December 1974
- DOI:
- 10.1073/pnas.71.12.5014
- Bibcode:
- 1974PNAS...71.5014U