Independent Segregation of the H-2 Locus and the Locus for Responsiveness to Histamine-Sensitizing Factor

The inheritance of responsiveness to histamine-sensitizing factor of pertussis bacilli was examined in (SWR/J x CBA/J)F₁ x CBA/J backcross mice. We found that about half of the backcross mice inherited this responsiveness in both sexes. There was no linkage between the inheritance of responsiveness to histamine-sensitizing factor and the H-2^q locus from the sensitive SW/J progenitor.