1,25-Dihydroxycholecalciferol: Identification of the Proposed Active Form of Vitamin D3 in the Intestine
Abstract
The major polar metabolite of cholecalciferol (vitamin D3) present in chick intestinal mucosa has been chemically characterized by mass spectrometric analysis to have a molecular formula of C27H44O3 and a structure of 1,25-dihydroxycholecalciferol. This compound, which is produced in the kidney from 25-hydroxycholecalciferol, has been previously shown to be from 4 to 13 times as active as cholecalciferol in stimulating intestinal calcium transport. 1,25-Dihydroxycholecalciferol (previously designated metabolite 4B in this laboratory) probably represents the biologically active form of cholecalciferol in the intestine.
- Publication:
-
Science
- Pub Date:
- July 1971
- DOI:
- 10.1126/science.173.3991.51
- Bibcode:
- 1971Sci...173...51N