Interferon and Transcription of Early Virus-Specific RNA in Cells Infected with Simian Virus 40
Abstract
Treatment with interferon reduced the content of early virus-specific RNA, as well as the content of an early viral protein (T antigen), in monkey cells acutely infected with simian virus 40 (SV40). This unexpected finding suggests either that the action of interferon involves inhibition of the transcription of early SV40 messenger RNA, or that the SV40 genome contains a "proto-early" gene whose product is required for the transcription of the remaining early genes.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- February 1971
- DOI:
- 10.1073/pnas.68.2.299
- Bibcode:
- 1971PNAS...68..299O