Chemical Basis of Hashish Activity
Abstract
A sample of hashish was extracted consecutively with petroleum ether, benzene, and methanol. When tested intravenously in monkeys only the petroleum-ether fraction was active. This material was further fractionated. The only active compound isolated was Δ 1-tetrahydrocannabinol. Cannabinol, cannabidiol, cannabichromene, cannabigerol, and cannabicyclol when administered together with Δ 1-tetrahydrocannabinol do not cause a change in the activity of the latter, under the experimental conditions used. These results provide evidence that, except for Δ 1-tetrahydrocannabinol, no other major, psychotomimetically active compounds are present in hashish.
- Publication:
-
Science
- Pub Date:
- August 1970
- DOI:
- 10.1126/science.169.3945.611
- Bibcode:
- 1970Sci...169..611M