Differences between the Ribonucleic Acids of Transforming and Nontransforming Avian Tumor Viruses
Abstract
The 60-70S RNAs of several transforming and nontransforming avian tumor viruses have different electrophoretic mobilities. The RNA of transforming viruses contains two electrophoretically separable subunit classes: a and b. The relative concentrations of these subunits vary with the virus strain. Avian leukosis viruses and nontransforming derivatives of a sarcoma virus lack subunits of class a. It is suggested that the presence of the class a subunit is related to the transforming ability for fibroblasts of the virus.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- December 1970
- DOI:
- 10.1073/pnas.67.4.1673
- Bibcode:
- 1970PNAS...67.1673D