Precipitation of Proteins by Vinblastine and Calcium Ions
Abstract
We have found that vinblastine sulfate can precipitate a number of proteins in addition to microtubule protein. Those proteins which precipitate with vinblastine sulfate, all of which were derived from structure, also precipitate with Ca2+ ions. Our results suggest that vinblastine sulfate, presumably acting as a cation, precipitates proteins by combining with sites which can also combine with Ca2+ ions.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- July 1970
- DOI:
- 10.1073/pnas.66.3.807
- Bibcode:
- 1970PNAS...66..807W