Implications of TL Phenotype Changes in an H-2-Loss Variant of a Transplanted H-2b/H-2a Leukemia
Abstract
An H-2-loss variant line, lacking H-2a antigens, was obtained from an H-2b/H-2a (C57BL × A)F1 transplanted leukemia by immunoselection. The TL phenotype of the unselected line was TL.1,2,3,4 and that of the variant TL.1,2,4, which is the phenotype of TL+ leukemias of C57BL. This finding, and the observed quantitative alterations of antigens TL.1,2 and 4, indicate that the Tla (Thymus leukemia antigen) locus was functionally deleted together with the H-2 locus in the process of variant formation, despite absence of selection against cells carrying TL antigens. Representation of H-2 antigens of the remaining haplotype, H-2b, was quantitatively unchanged.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- April 1970
- DOI:
- 10.1073/pnas.65.4.933
- Bibcode:
- 1970PNAS...65..933B