Stimulation of Mammalian Erythropoiesis by 5β -H Steroid Metabolites
Abstract
The effects of a number of steroid compounds on erythropoiesis in normal and polycythemic mice were examined. Of the steroids that stimulated erythropoiesis, the hormone testosterone and certain 5β-H C19 and C21 nonhormonal metabolites were the most effective. Anti-erythropoietin abolished the erythropoiesis-stimulating effects of testosterone but not those exerted by the 5β-H steroid, 11-ketopregnanolone. Similarly, testosterone but not 11-ketopregnanolone evoked the production of erythropoiesis-stimulating factor in rats. It is concluded that two mechanisms underlie the stimulating actions of steroids on erythropoiesis; one through the production of erythropoietin and the second involving a more direct influence on the blood-forming tissues. The 5β-H steroid metabolites are postulated to act on erythropoiesis via the latter mechanism.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- April 1970
- DOI:
- 10.1073/pnas.65.4.919
- Bibcode:
- 1970PNAS...65..919G