Cellular Sites of Immunologic Unresponsiveness
Abstract
The reconstitution of the immune response of lethally irradiated mice to human γ-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- March 1970
- DOI:
- 10.1073/pnas.65.3.551
- Bibcode:
- 1970PNAS...65..551C