Primary Structure of α-Lytic Protease: a Bacterial Homologue of the Pancreatic Serine Proteases
Abstract
Comparison of the amino-acid sequence of the bacterial α-lytic protease with the mammalian pancreatic proteases shows homologies in the regions of the N-terminus, the single histidine, an aspartic acid residue, the active serine, and in the positions of the three disulphide bridges. The partial sequence of a trypsin-like enzyme from Streptomyces griseus provides further evidence for divergent evolution of this class of enzymes from a common ancestral gene.
- Publication:
-
Nature
- Pub Date:
- October 1970
- DOI:
- 10.1038/228438a0
- Bibcode:
- 1970Natur.228..438O