Epinephrine Metabolism in Mammalian Brain after Intravenous and Intraventricular Administration
Abstract
Epinephrine given intravenously or intraventricularly has a half-life in the brain of the rat of 2 to 2.5 hours. After intravenous administration of the drug the principal route of metabolism is O-methylation, whereas after intraventricular administration the principal route is conjugation.
- Publication:
-
Science
- Pub Date:
- August 1969
- DOI:
- 10.1126/science.165.3893.616
- Bibcode:
- 1969Sci...165..616S