Mixed Culture Cytopathogenicity: A New Test for Growth of Murine Leukemia Viruses in Tissue Culture
Abstract
Tissue culture cells of a Rous virus-induced rat tumor undergo syncytium formation when placed in contact with mouse embryo cell cultures infected with murine leukemia viruses. This phenomenon can be used as a cytopathic end point for isolating and titrating these viruses in tissue culture. The principle should be applicable to detection of leukemia viruses of other species.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- July 1969
- DOI:
- 10.1073/pnas.63.3.753
- Bibcode:
- 1969PNAS...63..753K