Transformation and Chromosome Changes Induced by Epstein-Barr Virus in Normal Human Leukocyte Cultures
Abstract
Three separate attempts to establish long-term leukocyte cultures from the peripheral blood of a healthy adult who had no evidence of previous infection with Epstein-Barr virus were consistently unsuccessful. On the other hand, in vitro infection of buffy-coat cells of this donor with Epstein-Barr virus resulted in blastoid transformation of the lymphocytes and long-term growth potential. The transformation was accompanied by major chromosome changes. The significance of these findings in relation to lymphoproliferative diseases in man remains to be determined.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- July 1969
- DOI:
- 10.1073/pnas.63.3.740
- Bibcode:
- 1969PNAS...63..740G