Complex Mitochondrial DNA in Leukemic and Normal Human Myeloid Cells
Abstract
Mitochondrial DNA's from the peripheral blood of 14 patients with granulocytic leukemia contained a circular dimer form. No such structure could be found in M DNA's from three patients with nonmalignant proliferations of granulocytes. The frequency of the circular dimer form is reduced upon treatment with antileukemic drugs. The above results suggest that a significant relation exists between the formation and presence of the circular dimer M DNA form and granulocytic leukemia in man.
- Publication:
-
Proceedings of the National Academy of Science
- Pub Date:
- April 1969
- DOI:
- 10.1073/pnas.62.4.1077
- Bibcode:
- 1969PNAS...62.1077C