Structure of Papain
Abstract
A three-dimensional X-ray study at a resolution of 2.8 Å has revealed that the single polypeptide chain of 211 residues is folded into two distinct parts which are divided by a cleft. The active site, consisting of a cysteine and a histidine, lies at the surface of the cleft. Apart from four short α-helical segments and one short segment of β-structure, the conformation of the chain is irregular.
- Publication:
-
Nature
- Pub Date:
- June 1968
- DOI:
- 10.1038/218929a0
- Bibcode:
- 1968Natur.218..929D