A photometric investigation in the UBV system of the galactic cluster NGC 2281 is presented. Thirty-seven stars were observed photoelectrically, and 121 stars photographically. A distance modulus of 8 4 mag, obtained by using the Johnson evolutionary deviation diagram, yields a distance to the cluster of 480 pc, in good agreement with the only previous photoelectric work done by Pesch, which gave a distance modulus of 8.5 mag. The color-color diagram gives an E(b - v) of 0.10 mag. An age of the cluster of 5.5 X 108 years is derived using the nuclear time-scale formula for the brightest main-sequence star The cluster membership from proper-motion studies consists of fifty-five stars to V = 13. From a photographic analysis of the neighboring field it is possible to predict that there are few, if any, members beyond this range of magnitude.