Modification of the Radiation Effect on Ascitic Tumour Cells by Pharmacological Agents injected intravenously
THE modification of the effect of radiation on a murine ascitic tumour irradiated in vivo by pharmacological agents has been previously reported1-3. In those investigations the effect of radiation on the reproductive capacity of ascitic tumour cells was modified by direct injection of the pharmacological agent into the peritoneal cavity, the site of tumour growth. The experiments reported here were performed with intravenous injection of the agent to utilize physiological processes in the host (tumour bearing) animal to transport the pharmacological agent to the site of the tumour. It was our belief that although the concentration of the agent at the site might be limited, the technique would more closely simulate clinical situations where it is frequently not possible to achieve high concentration of a drug at the site of the tumour. The modifications of the effect of radiation on the tumour cells could be measured quantitatively by changes in radiation survival curve parameters.