Tremorine: Its Effect on Amines of the Central Nervous System
Abstract
The administration of tremogenic doses of Tremorine, 1,4-dipyrrolidino-2-butyne, is followed by a significant decrease in the concentration of norepinephrine in the brain stem of three common laboratory species. The change in the concentration proceeds at a rate which coincides with the occurrence of the tremor in each of these species. In the rat, the change in nor-epinephrine is followed by a progressive increase in the concentration of 5-hydroxytryptamine in the brain stem. Bilateral adrenalectomy in the rat enhances the Tremorine-induced changes in the concentration of norepinephrine and antagonizes the increase in the concentration of 5-hydroxytryptamine.
- Publication:
-
Science
- Pub Date:
- September 1963
- DOI:
- 10.1126/science.141.3586.1188
- Bibcode:
- 1963Sci...141.1188F