Enzymatic Formation of Psychotomimetic Metabolites from Normally Occurring Compounds
Abstract
An enzyme has been found that N-methylates serotonin and tryptamine to psychotomimetic metabolites, bufotenine and N,N-dimethyltryptamine. This enzyme is highly localized in the rabbit lung and also N-methylates phenylethylamine derivatives such as tyramine, phenylethylamine, mescaline, and dopamine.
- Publication:
-
Science
- Pub Date:
- August 1961
- DOI:
- 10.1126/science.134.3475.343
- Bibcode:
- 1961Sci...134..343A