Serological Procedure for the Detection of Antibodies to Penicillin
Abstract
A hemagglutination technique for demonstrating antibodies to penicillin in sera from penicillin-allergic subjects is described. Erythrocytes coupled to penicillin T by means of bis-diazotized-benzidine constitute the "antigen" used to measure the antipenicillin antibody. The hemagglutination reaction is highly specific, as indicated by hemagglutination-inhibition studies. The clinical significance of these antibodies remains to be elucidated.
- Publication:
-
Science
- Pub Date:
- November 1959
- DOI:
- 10.1126/science.130.3387.1472
- Bibcode:
- 1959Sci...130.1472E