Use of `Tremorine' for screening Anti-Parkinsonian Drugs
Abstract
`TREMORINE' (1 : 4-dipyrrolidine-butyne) has been proposed1,2 as a test drug against which anti-Parkinsonian agents may be screened and evaluated by their effect on the tremor induced by `Tremorine' in mice. We have investigated the action of the compound in toads, mice, rats and guinea pigs; trials with larger animals, dogs and cats, were restricted by the shortage of `Tremorine'.
- Publication:
-
Nature
- Pub Date:
- May 1959
- DOI:
- 10.1038/1831462a0
- Bibcode:
- 1959Natur.183.1462T