Noradrenaline and Accessory Chromaffin Tissue
Abstract
Fulk and Macleod1 showed that the retro-peritoneal tissue of many mammals contains a material which, like extracts of the suprarenal glands, produces inhibition of the isolated rabbit intestine and excitation of the isolated rabbit uterus. Using histological methods, Wislocki2 confirmed that there is abdominal chromaffin tissue in these animals. Whereas Mulon3 showed that the chromaffin tissue in the carotid bodies of horses contains a pressor substance, Fulk and Macleod1 failed to obtain any sympathomimetic substance in extracts of the thoracic aorta (containing the chromaffin tissue of the cardioaortic bodies). Recently, West, Shepherd and Hunter4 reported that the collection of chromaffin tissue known in babies as the organs of Zuckerkandl contains large amounts of noradrenaline. The paraganglia are situated along the aorta near the origin of the inferior mesenteric artery. We have therefore attempted (a) to confirm that a sympathomimetic substance is present in accessory chromaffin tissue of animals, and (b) to identify such a substance by biological and chromatographic methods4.
- Publication:
-
Nature
- Pub Date:
- July 1952
- DOI:
- 10.1038/170042b0
- Bibcode:
- 1952Natur.170...42S