(1) Among the 445 persons taking the vaccine, 399 had 1,089 (70 per cent.) less colds this year than usual, whereas the 469 controls showed a decrease of only 299 (26.3 per cent.) colds, an essential decrease of 43.7 per cent. due to oral cold vaccine. (2) It was stated by 326 (81.7 per cent.) of the 399 persons taking the vaccine that they had been greatly benefited. (3) Of forty-six persons who had previously been troubled with practically continuous colds, three reported that they were not helped while taking the vaccine, while the remaining forty-three, suffering a total of only thirty-four colds during this winter, were greatly benefited. In other words, these forty-three persons, previously in a state of practically continuous coryza, suffered from less than one cold per person during this season. (4) The oral vaccine makes frequent administration practical, which is so essential in such short life immunities as occur with the bacteria of upper respiratory infections.