The Na/K pump, Cl ion, and osmotic stabilization of cells
Abstract
An equation for membrane voltage is derived that takes into account the electrogenicity of the Na/K pump and is valid dynamically, as well as in the steady state. This equation is incorporated into a model for the osmotic stabilization of cells. The results emphasize the role of the pump and membrane voltage in lowering internal Cl concentration, thus making osmotic room for vital substances that must be sequestered in the cell.
- Publication:
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Proceedings of the National Academy of Science
- Pub Date:
- May 2003
- DOI:
- 10.1073/pnas.0931278100
- Bibcode:
- 2003PNAS..100.6257A
- Keywords:
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- Physiology