Self-Assembled Organic Monolayers: Model Systems for Studying Adsorption of Proteins at Surfaces
Abstract
Self-assembled monolayers (SAMs) of ω-functionalized long-chain alkanethiolates on gold films are excellent model systems with which to study the interactions of proteins with organic surfaces. Monolayers containing roes of hydrophobic (methyl- terminated) and hydrophilic [hydroxyl-, maltose-, and hexa(ethylene glycol)-termi- nated] alkanethiols can be tailored to select specific degrees of adsorption: the amount of protein adsorbed varies monotonically with the composition of the monolayer. The hexa(ethylene glycol)-terminated SAMs are the most effective in resisting protein adsorption. The ability to create interfaces with similar structures and well-defined compositions should make it possible to test hypotheses concerning protein adsorption.
- Publication:
-
Science
- Pub Date:
- May 1991
- DOI:
- 10.1126/science.252.5009.1164
- Bibcode:
- 1991Sci...252.1164P