Brain-Derived Acidic Fibroblast Growth Factor: Complete Amino Acid Sequence and Homologies
Abstract
Bovine brain-derived acidic fibroblast growth factor (aFGF) is a protein mitogen originally identified in partially purified preparations of whole brain. The protein was purified to homogeneity and shown to be a potent vascular endothelial cell mitogen in culture and angiogenic substance in vivo. The homology of aFGF to human interleukin-1β was inferred from partial sequence data. The complete amino acid sequence of aFGF has now been determined and observed to be similar to both basic FGF and interleukin-1's. A neuropeptide-like sequence, flanked by basic dipeptides, was observed within the aFGF sequence.
- Publication:
-
Science
- Pub Date:
- December 1985
- DOI:
- 10.1126/science.4071057
- Bibcode:
- 1985Sci...230.1385G