Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus
Abstract
A partial amino acid sequence of human platelet-derived growth factor, the major mitogen in serum for cells of mesenchymal origin, has been determined. A region of 104 contiguous amino acids shows virtual identity with the predicted sequence of p28sis, the putative transforming protein of simian sarcoma virus (SSV). This similarity suggests a mechanism for transformation by SSV and other agents, involving expression of growth factors.
- Publication:
-
Nature
- Pub Date:
- July 1983
- DOI:
- 10.1038/304035a0
- Bibcode:
- 1983Natur.304...35W