The coding function of nucleotide sequences can be discerned by statistical analysis
Abstract
The nucleotide sequences of the RNA phage MS2 and the DNA phage φX were subjected to statistical analysis. This analysis alone indicates (a) that the genetic code is a non-overlapping triplet code and (b) what the correct reading frame is. The application of these methods to identify structure in sequences of unknown function is discussed.
- Publication:
-
Journal of Theoretical Biology
- Pub Date:
- 1981
- DOI:
- 10.1016/0022-5193(81)90274-5
- Bibcode:
- 1981JThBi..88..409S